Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α(PPARα) and the Target Gene in the Liver of Hyperlipemia Rat
Ye Yong~1, Wang Jianing~2, Wang Daowen~2, et al. Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α(PPARα) and the Target Gene in the Liver of Hyperlipemia Rat[J]. Journal of Traditional Chinese Medicine2006, (1): 53-55.
Ye Yong~1, Wang Jianing~2, Wang Daowen~2, et al. Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α(PPARα) and the Target Gene in the Liver of Hyperlipemia Rat[J]. Journal of Traditional Chinese Medicine2006, (1): 53-55.DOI: 10.13288/j.11-2166/r.2006.01.036.
Objective:To observe effects of Huatan Huoxue Prescription on expressions of peroxisome proliferation substance activating receptor α (PPAR α) and the target gene acetyl-CoA oxidase(ACO) in the liver of the rat with hyperlipemia.Methods:The rats of hyperlipemia were treated respectively with Huatan Huoxue Prescription of large
middle
small dosages and Lipanthyl
and related indexes were detected.Results:The Huatan Huoxue Prescription could significantly decrease level of serum total cholesterol(TC) and triglyceride(TG)
and strengthened expressions of PPARα and ACO mRNA in the liver of hyperlipemia rats.Conclusion:Increase of expressions of PPARα and ACO mRNA is possibly one of the mechanisms of Huatan Huoxue Prescription in treatment of hyperlipemia.