Objective:To evaluate the short-term and middle-term therapeutic effects and the safety of deep acupuncture at Tianshu（ST 25） for treatment of slow transit constipation（STC）.Methods:60 cases of STC were randomly divided into an acupuncture group and a control group.Cleveland Constipation Score（CCS） and colic transit time（CTT） before treatment

2 weeks and 6 months after the treatment were investigated

and the safety was evaluated by clinical

laboratory and imaging indexes.Results:For the short-term therapeutic effect

the treatment group was better than the control group（P<0.01） in clinical score and therapeutic effect of CTT;and for the middle-term therapeutic effect

the treatment group was effective and the control group was ineffective 6 months after treatment

the treatment group superior to the control group（P<0.01）.No adverse reaction was found in the treatment group.Conclusion:Deep acupuncture at Tianshu（ST 25） has a definite short-term therapeutic effect

and some middle-term therapeutic effect on STC

with no adverse reaction.