Objective:To observe effects of Yiqi Yangyin Jiedu Fang on serum vascular endothelial growth factor（VEGF） and Immunologic function in the patient of non-small cell lung cancer（NSCLC）.Methods:Fifty-one cases of NSCLC were randomly divided into a Chinese medicine group

a chemotherapy group and a chemotherapy plus Chinese medicine group.The therapeutic effect and changes of clinical symptoms

physical strength

immunologic indexes and serum VEGF before and after treatment were investigated in all groups.Results:Tumor stable rate in Chinese medicine group and chemotherapy plus Chinese medicine group after treatment was higher than that in chemotherapy group with no significant difference

but improvement of clinical symptoms and physical strength in Chinese medicine group and chemotherapy plus Chinese medicine group after treatment was significantly superior to that in chemotherapy group（both P<0.05）.Interleukin-2（IL-2） level was significantly increased

and soluble IL-2 receptor（sIL-2R） were down-regulated（both P<0.01） in Chinese medicine plus chemotherapy group

and the therapeutic effect was significantly higher than that of the chemotherapy group（P<0.05）; The total T-cell count was significantly increased and the sIL-2 level was down-regulated in Chinese medicine group（P<0.05 or P<0.01）.Serum VEGF level significantly decreased after treatment in the Chinese medicine plus chemotherapy group（P<0.01）.Conclusion:Yiqi Yangyin Jiedu Fang has functions of reducing and stabilizing the tumor focus

increasing immunologic function and quality of life

and decreasing VEGF level for the patient of NSCLC.