Tang Xudong, Ma Rou, Liu Feng, et al. Study on Correlativity of Expression of T-Cell CD45RA/RO with TCM Syndrome Types in the Patient of Aplastic Anemia[J]. Journal of Traditional Chinese Medicine2006, (3): 212-214. DOI: 10.13288/j.11-2166/r.2006.03.034.
Tang Xudong, Ma Rou, Liu Feng, et al. Study on Correlativity of Expression of T-Cell CD45RA/RO with TCM Syndrome Types in the Patient of Aplastic Anemia[J]. Journal of Traditional Chinese Medicine2006, (3): 212-214. DOI: 10.13288/j.11-2166/r.2006.03.034.DOI:
Objective:Adopting statistical method to establish differentiating equation for TCM syndrome types of aplastic anemia(AA)
and to probe the relationship between T-cell CD
45 RA/RO and TCM syndrome types.Methods:Immunological indexes of peripheral blood were determined in 34 cases of AA and 34 healthy persons with flow cytometry
and classification of TCM syndromes was carried out in the patients of AA.Results:The most significant 5 indexes screened such as CD
45 RA
+
absolute value
constituted the differentiating equation of classification of AA syndromes
with the total correct differentiating rate of 76.5%. CD
8
+
CD
45 RO
+
expression(%) in all the AA syndrome types increased significantly as compared with healthy control group(P
<
0.05 or P
<
0.01).Conclusion:CD
8
+
CD
45 RO
+
(%) expression in AA patient increases significantly
confirming that after abnormal activation
T-cells in AA patient transform as memory T-cells
and further lead to immunologic pathogenic mechanism of bone marrow exhaustion
indicating that TCM syndrome classification has a definitely objective substance basis. The obvious changes of CD
45 RA
+
absolute value in the syndrome classification can be used as an objective index for TCM syndrome type of AA.