Objective:To explore effects of Conggan Zhixin Prescription （CGZXP） on vascular endothelial growth factor（VEGF） expression in multiple organs in acute myocardiac infarction（AMI） rats.Methods:AMI model rats were divided into a CGZXP group and a saline （NS） group.Plasma and tissue protein of different parts were prepared on 3rd

7th

14th and 21st day;Drug-containing serum were prepared in high

middle and low doses of CGZXP and NS groups.VEGF levels in the above serum

plasma and tissues were determined with ELISA.Results:There was no expression or micro-expression of VEGF in drug-containing serum in all groups

and plasma

lung and spleen tissues in AMI rats;The secretion of VEGF could be determined in the heart

liver

kidney and brain of the model group at all time points.Among them

VEGF content in the myocardium of the juncture of infarction was higher than that in the center of the infarction myocardium.In CGZXP group

VEGF expression in the infarction center on 7th day of AMI

in the liver on 3rd day of AMI

in the heart

liver

kidney and brain at all time points significantly upregulated with a significant difference as compared with NS group（P<0.01）.Conclusion:CGZXP can upregulate VEGF protein expression in ischemic myocardium in AMI rats

and promote secretion of VEGF in the kidney

brain

liver after AMI

and has a certain protective action on ischemic injury of multiple organs after AMI.