Tan Bin. Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia[J]. Journal of Traditional Chinese Medicine2006, (5): 361-362.
Tan Bin. Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia[J]. Journal of Traditional Chinese Medicine2006, (5): 361-362.DOI: 10.13288/j.11-2166/r.2006.05.023.
Objective:To probe the therapeutic effect and adverse reaction of Wendan Decoction in combination with Clozapine for treatment of schizophrenia.Methods:Three groups were set up in the study
30 cases in each.The group Ⅰ were treated with Wendan Decoction
group Ⅱ with Wendan decoction plus Clozapine
and the control group with Clozapine.Positive and negative symptom scale(PANSS)and treatment emergent symptom scale(TESS)were used for evaluation of the therapeutic effect and adverse reaction.Results:The markedly effective rate was 70% and the effective rate was 30% in group Ⅱ
36.6% and 50% in the group Ⅰ
and 43.6% and 56.4% in the control group respectively.The adverse reactions in group Ⅰ and group Ⅱ were less than those in the control group.Conclusion:Wendan Decoction has a definite therapeutic effect on schizophrenia and the combined treatment has better therapeutic effect with high safety.It can improve symptoms and reduce the dosage of antipsychotics and the incidence of EPS.