Liu Wei~1, Zhou Yonghong~2, Fu Xianjun~3, et al. Effects of Fujian Tablets on Expression of GFAP and GAP-43 in Brain Tissue of Ischemic Stroke Sequela Model Rats[J]. Journal of Traditional Chinese Medicine2006, (5): 378-380.
Liu Wei~1, Zhou Yonghong~2, Fu Xianjun~3, et al. Effects of Fujian Tablets on Expression of GFAP and GAP-43 in Brain Tissue of Ischemic Stroke Sequela Model Rats[J]. Journal of Traditional Chinese Medicine2006, (5): 378-380.DOI: 10.13288/j.11-2166/r.2006.05.035.
Objective:To explore effects of Fujian Tablets on activity of astrocytes and axonal regeneration in the ischemic stroke sequela model rat.Methods:The ischemic stroke sequela model rat was established by middle cerebral artery occlusion(MCAO).Glial fibrillary acid protein(GFAP)and growth-associated protein-43(GAP-43)were determined with immunohistochemical method and were used to evaluate the effects of Fujian Tablets on the activity of astrocytes and axonal regeneration.Results:Fujian Tablets increased expressions of both GFAP and GAP-43 in the brain of MCAO rat
and there was significantly positive correlativity between GFAP and GAP-43 expressions.Conclusion:Fujian Tablets can promote axonal regeneration and induce remodeling of nervous functions in the ischemic stroke sequela model rat
which are related with improving action of Fujian Tablets on activity of astrocytes.