Wang Yongxia~1, Dang Weiyi~2, Chen Zhaoqi~3, et al. Comparative Study on Effects of Three Therapeutic Methods on Vascular Remodeling in Spontaneous Hypertension Rats[J]. Journal of Traditional Chinese Medicine2006, (5): 381-383.
Wang Yongxia~1, Dang Weiyi~2, Chen Zhaoqi~3, et al. Comparative Study on Effects of Three Therapeutic Methods on Vascular Remodeling in Spontaneous Hypertension Rats[J]. Journal of Traditional Chinese Medicine2006, (5): 381-383.DOI: 10.13288/j.11-2166/r.2006.05.037.
and combination of both methods on vascular remodeling(VR)in spontaneous hypertension rats(SHR).Methods:SHR were randomly divided into resolving dampness group
calming the liver group
calming the liver and resolving dampness group
Enalapril group and model group
with the Wistar-Kyoto(WKY)rats used as normal control group.They were treated for 8 weeks.Changes of blood pressure
aortic collagen content
and its vascular smooth muscle(VSM)
collagen fibers(CF)
area of elastic fibers(EF)were investigated in all groups.Results:The blood pressure
aortic collagen content
VSM and CF area in the model group were significantly higher than those in other groups(P<0.05 or P<0.01);and the number of the nucleus of vascular smooth muscle cells(VSMC)in the model group was significantly less than that in WKY group
calming the liver and resolving dampness group
and Enalapril group.There was significant difference between model group and WKY group in changes of EF.Conclusion:All the 3 therapeutic methods have functions of decreasing blood pressure
inhibiting deposition of aortic collagen and overgrowth of VSMC.