Liu Cunzhi~1, Yu Jianchun~1, Wang Tong~2, et al. Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats[J]. Journal of Traditional Chinese Medicine2006, (7): 502-504.
Liu Cunzhi~1, Yu Jianchun~1, Wang Tong~2, et al. Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats[J]. Journal of Traditional Chinese Medicine2006, (7): 502-504.DOI: 10.13288/j.11-2166/r.2006.07.017.
Objective:To probe into effects of acupuncture on nitric oxide (NO) and nitric oxide synthetase(NOS) in multi-infarctional dementia(MID) rats.Methods:MID rats were randomly divided into model group
acupuncture group
non-acupoint group
normal group and sham-operation group.NO contents and NOS activities in serum and different brain regions
and nNOS gene expression in different brain regions were investigated.Results:NO contents in serum
cortex and hippocampus
NOS activities in hippocampus and striatum
and expressions of nNOS mRNA and protein in different regions increased in model group as compared with those of normal group.Acupuncture could significantly reverse the above abnormal changes.Conclusion:Acupuncture can inhibit over-expression of nNOS
decrease activity of NOS and reduce NO generation in MID rats
so as to exert a certain nerve protective action via NO/NOS pathway.