Objective:To observe effect of Xianling Gusong Capsules and Fosamax in prevention and treatment of osteoporosis（OP） induced by glucocorticoid（GC）

and to compare their clinical therapeutic effects and adverse effects.Methods:The patients needing long-term administration of GC were randomly divided into treatment group Ⅰ

treatment group Ⅱ

prevention group Ⅰ

and prevention group Ⅱ

and they were treated with oral administration of Xianling Gusong Capsules and Fosamax

respectively.Bone mineral density（BMD）

indexes of bone metabolism before and after treatment and adverse effects were investigated.Results:In the two treatment groups

BMD of L

2

4

and neck of femur significantly increased（P

<

0.05）

and BGP

urinary pyridinoline（U-PYD）/creatinine（Cr） and urinary deoxy-pyridinoline（U-DPD）/Cr significantly decreased after treatment （P

<

0.05 or P

<

0.01）.Blood Ca and P did not have significant change（P

>

0.05）.In the prevention groups

after treatment

BMD of L

2

4

and neck of femur

BGP

U-PYD/Cr

U-DPD/Cr

and blood Ca and P levels did not significant changes （P

>

0.05）.Conclusion:Both Xianling Gusong Capsules and Fosamax have clinical effects in prevention and treatment of GC-induced osteoporosis

but Xianling Gusong Capsules has more remarkable therapeutic effect and less adverse effects.