Objective:To study the effect of Yougui Wan on experimental hypothyroidism and GluT4 mRNA expression in the skeletal muscle of experimental hypothyroidism rats.Methods:Experimental hypothyroidism rat model was made with intragastrical perfusion of propylthiouracil（PUT） and was treated with different treatment programs.After treatment for 8 weeks

the rats were killed and the blood sample was taken for examination of thyroid hormones

and the muscular tissue was taken to detect GluT4 mRNA expression.Results:GluT4 mRNA expression in the skeletal muscle significantly decreased in the model group

corresponding to 14.37% of the normal expression; After treatment

the GluT4 mRNA expression significantly increased to about the normal range in the Yougui Wan mid dose group

Yougui Wan high dose group

and the integrated Chinese and western medicine group.There was no significant changes as the western medicine group

Yougui Wan low dose group

self-stipulated recipe group compared with the model group.Conclusion:Yougui Wan can up-regulate GluT4 mRNA expression in the skeletal muscle of hypothyroidism rats

promoting transport of glucose in the skeletal muscle

so as to improve energy metabolism of the skeletal muscular cells

which is possibly one of the mechanisms of the Chinese medicine effectively treating hypothyroidism.