Objective:To evaluate clinical therapeutic effect of Wubi Capsule on systemic scleroderma （SSc） and its effects on level of endothelial cell in peripheral blood circulation.Methods:Sixty-five cases of SSc meeting the enrolled criteria were randomly divided into a treatment group and a control group by using double blind and double simulation method.Cumulative scores of clinical symptoms

changes of peripheral endothelial cell contents were compared prespectively between the two groups.Results:The vascular endothelial cell level significantly increased in the patient of SSc as compared with that of healthy subjects（P<0.01）.After treatment

cumulative scores of clinical symptoms and vascular endothelial cell level decreased significantly in both groups（P<0.05 orP<0.01）;The treatment group was superior to the control group in the aspects of total effective rate

antibody-negative rate and the decrease of endothelial cell level in the circulation（P<0.05 or P<0.01）.Conclusion:Wubi Capsule can significantly improve clinical symptoms and signs

increase quality of life in the patient of SSc

and protection vascular endothelial cell might be one of its mechanisms.