Objective:To study on peripheral blood gene expression profile in the obesity with phlegm-dampness constitution by gene chip technique.Methods:Three cases of non-phlegm-dampness constitution

2 cases of phlegm-dampness constitution

and 3 normal persons were selected and the extracted total RNA was magnified and labeled.Then the quality of samples was detected and the gene expression profile was investigated.The genes marked by the sequence with statistically significant difference were searched out from Gene Bank.Results:As the phlegm-dampness constitution compared with the non-phlegm-dampness constitution

there are 115 probe groups of differential expression.Conclusion:There were significant differences of peripheral blood relative genes expression between the phlegm-dampness constitution and the non-phlegm-dampness constitution.