Objective:To observe the therapeutic effect of Dangfei Liganning combined with Matrine on hepatic fibrosis in patients of different hepatic diseases infected by hepatitis B virus.Methods:Determine serum hepatic fibrosis indexes before and 6 months after treatment with RIA in 123 cases of different hepatic diseases treated with Dangfei Liganning combined with Matrine

and 31 cases of chronic hepatitis B treated with simple Matrine.Results:Of the 123 cases of different hepatic diseases

hepatic fibrosis indexes in hepatitis B virus carriers

chronic hepatitis B patients and the patients of liver cirrhosis at compensatory phase decreased significantly（P<0.05 or P<0.01） after treatment

but the indexes in the patients of liver cirrhosis at decompensatory phase did not significantly change（P>0.05）.After treatment with Dangfei Liganning combined with Matrine

the hepatic fibrosis indexes in the patients of chronic hepatitis B significantly decreased（P<0.01） with a better therapeutic effect than that of simple Matrine（P<0.05）.Conclusion:Dangfei Liganning combined with Matrine can significantly decrease hepatic fibrosis indexes in hepatitis B virus carriers

patients of chronic hepatitis B and liver cirrhosis at compensatory phase

arresting or delaying development of lesion in the patient of liver cirrhosis at the decompensatory phase

with a significantly better therapeutic effect than simple Matrine.