Objective:To observe the therapeutic effect and mechanisms of Puerarin injection combined with vitamin C for treatment of type II diabetic nephropathy.Methods:On the basis of routine treatment

145 cases of type II diabetic nephropathy were randomly divided into a treatment group（n=52） treated with intravenous drip of Puerarin injection and vitamin C

a control group A（n=48） treated with intravenous drip of simple Puerarin injection

and a control group B（n=45） treated with simple vitamin C.Two weeks constituted one course.Changes of urea nitrogen

serum creatinine

blood lipid

glycosylated hemoglobin

MDA

SOD and 24-hour urine albumin excretion rate before and after treatment were investigated. Results: After treatment

investigated indexes except urea nitrogen

serum creatinine and glycosylated hemoglobin

improved significantly in the treatment group （P<0.01）.Conclusion:Puerarin injection and vitamin C can markedly improve renal function and decrease urinary protein excretion rate with synergistic action.The effect of combined use on type Ⅱ diabetic nephropathy is superior to that of simple Puerarin injection or vitamin C.