Wang Lei, Liu Ping, Mu Yongping, et al. Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats[J]. Journal of Traditional Chinese Medicine2006, (12): 929-932.
Wang Lei, Liu Ping, Mu Yongping, et al. Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats[J]. Journal of Traditional Chinese Medicine2006, (12): 929-932.DOI: 10.13288/j.11-2166/r.2006.12.031.
Objective:To probe into TCM recipe and syndrome of dimethylnitrosamine(DMN)-induced hepatic fibrosis of the rat.Methods:DMN rat hapetic fibrosis model was prepared by intraperitoneal injection of DMN
and they were respectively treated with 5 classical recipes with difference functions for 2 weeks.Changes of pathology of the hepatic tissue
hydroxyproline(Hyp) content and hapetic function were investigated.Results:4 weeks after modeling
typical micronodular cirrhosis formed
and 6 weeks after modeling
the hepatic injury in the model group had some remission as compared with that at 4 weeks.Compared with the model group at 6 weeks
pathologic changes of the hepatic tissue
Hyp content and hepatic function improved significantly(P<0.05 or P<0.01) in the Inchenhao Decoction group;pathologic changes of the hepatic tissue and Hyp content in the Huangqi Decoction group improved significantly(P<0.05 or P<0.01).Conclusion:Inchenhao Decoction and Huangqi Decoction can effectively reverse DMN-induced hepatic fibrosis of rats;damp-heat
stagnation of heat in the interior with qi-deficiency are main TCM syndromes of DMN hepatic fibrosis rat at the formative stage.