Objective To observe the therapeutic effect of Pinggan Yishen Ditan Decoction （Liver-Calming Kidney-Boosting Phlegm-Flushing Decoction） for hypertensive obesity and its possible mechanism.Methods Sixty cases of hypertensive obesity were randomly divided into Chinese medicine group （Chinese medicine was added on the basis of treatment in control group） and control group.The treatment course lasted for 8 weeks.Blood pressure （BP）

body weight

waist circum-ference（WC）

waist-to-hip ratio（WHR）

metabolism parameters

fasting insulin（FINS） and Leptin were observed and compared before and after treatment.Results There was significant difference in SBP

DBP

BMI

WC

WHR

FPG

TC

TG

HDL-C

LDL-C

FINS

Leptin and ISI after treatment in Chinese medicine group （P<0.05 or P<0.01）

and there was significant difference in SBP

DBP FPG TC

HDL-C

LDL-C and ISI between the two groups （P<0.05）.Conclusion Chinese medicine treatment can improve BP

body weight and BMI and regulate metabolism parameters for hypertensive obesity on the basis of moderate exercises

rational diet and enalapril meleate

which maybe relvant to its increasing insulin sensitivity and decreasing Leptin.