保肝解毒颗粒对雷公藤多苷所致急性肝损伤小鼠白介素18及细胞凋亡的影响

彭勃; 禄保平; 苗明三; 杨晓娜; 许家艳

doi:10.13288/j.11-2166/r.2007.02.042

您当前的位置：

首页 >

文章列表页 >

保肝解毒颗粒对雷公藤多苷所致急性肝损伤小鼠白介素18及细胞凋亡的影响

百家园 | 更新时间：2021-11-17

- 保肝解毒颗粒对雷公藤多苷所致急性肝损伤小鼠白介素18及细胞凋亡的影响
- Effects of Baogan Jiedu Granules on IL-18 and Apoptosis in Acute Liver Injury Mice Induced by Tripterygium Wilfordii Polyglycoside
- 中医杂志 2007年第2期页码：169-171
- 作者机构：
  
  1. 河南中医学院肝病研究所
  2. 河南中医学院肝病研究所河南省郑州市金水路1号,450008
- 作者简介：
- 基金信息：
  
  河南省科技攻关项目（0324410026）
- DOI：10.13288/j.11-2166/r.2007.02.042
  中图分类号： R285
- 纸质出版：2007
- 稿件说明：
移动端阅览
[1]彭勃,禄保平,苗明三,杨晓娜,许家艳.保肝解毒颗粒对雷公藤多苷所致急性肝损伤小鼠白介素18及细胞凋亡的影响[J].中医杂志,2007(02):169-171.

PENG Bo, LU Bao-ping, MIAO Ming-san, et al. Effects of Baogan Jiedu Granules on IL-18 and Apoptosis in Acute Liver Injury Mice Induced by Tripterygium Wilfordii Polyglycoside[J]. Journal of Traditional Chinese Medicine2007, (2): 169-171.
[1]彭勃,禄保平,苗明三,杨晓娜,许家艳.保肝解毒颗粒对雷公藤多苷所致急性肝损伤小鼠白介素18及细胞凋亡的影响[J].中医杂志,2007(02):169-171. DOI： 10.13288/j.11-2166/r.2007.02.042.

PENG Bo, LU Bao-ping, MIAO Ming-san, et al. Effects of Baogan Jiedu Granules on IL-18 and Apoptosis in Acute Liver Injury Mice Induced by Tripterygium Wilfordii Polyglycoside[J]. Journal of Traditional Chinese Medicine2007, (2): 169-171. DOI： 10.13288/j.11-2166/r.2007.02.042.

摘要

目的探讨药物性肝损伤的发病机理及保肝解毒颗粒的作用机制。方法60只小鼠随机分为6组

分别以相应剂量药物灌胃5天

再以雷公藤多苷灌胃造模

检测小鼠血清丙氨酸氨基转移酶（ALT）、血清门冬氨酸氨基转移酶（AST）和白介素18（IL-18）水平及肝细胞凋亡情况。结果模型组IL-18明显升高

肝细胞凋亡严重;保肝解毒颗粒可有效降低ALT、AST和IL-18水平

并使肝细胞凋亡程度明显减轻。结论雷公藤多苷所致的急性肝损伤与IL-18和肝细胞凋亡密切相关;保肝解毒颗粒可通过降低-18水平、抑制肝细胞凋亡等起到防治肝脏损害的作用。

Abstract

Objective To explore the pathogenesis of drug-induced liver injury and the therapeutic mechanism of Baogan Jiedu Granules.Methods Totally 60 mice were randomly divided into 6 groups.They were treated with intragastrical perfusion of corresponding doses of drugs for 5 days

respectively and then were modeled by intragastrical perfusion of Tripterygium Wilfordii Polyglycoside.Serum ALT

AST and IL-18 levels and apoptosis of hepatic cells were detected.Results IL-18 level in model group increased obviously with severe apoptosis of hepatic cells.Baogan Jiedu Granules could effectively decrease ALT

AST activities and IL-18 level with apoptosis of hepatic cells obviously improved.Conclusion Leigongteng Duodai-induced acute liver injury is closely correlated with IL-18 and apoptosis of hepatic cells.Baogan Jiedu Granules has therapeutic effect for liver injury through decreasing IL-18 level and inhibiting apioptosis of hepatic cells.

关键词

Keywords

references

查看原文

浏览量

340

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

益胃汤对初老雌性大鼠卵巢细胞凋亡线粒体通路的影响

基于NLRP3/Caspase-1/IL-1β信号通路探讨通窍明目Ⅳ号方含药血清对L-谷氨酸诱导R28细胞损伤的影响

补肾调经方对重复控制性卵巢刺激模型小鼠囊胚细胞凋亡及内质网应激的影响

健脾益肾化痰方含药血清对人肺鳞癌细胞凋亡、迁移及LncRNA ALAL-1/USP4/HDAC2通路的影响

枳壳甘草汤对椎间盘退变模型大鼠尾椎间盘髓核组织细胞凋亡及Hippo-YAP/TAZ信号通路的影响