肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β<sub>1</sub>的影响

焦扬; 关天宇; 周平安

doi:10.13288/j.11-2166/r.2007.03.039

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肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β₁的影响

方药研究 | 更新时间：2021-11-17

- 肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β₁的影响
- Effect of Feibi Decoction on p38 MAPK and Transforming Growth Factor β₁ of Pulmonary Tissue in Rats with Pulmonary Fibrosis
- 中医杂志 2007年第3期页码：259-261
- 作者机构：
  
  1. 北京中医药大学东方医院呼吸科
  2. 北京中医药大学东方医院呼吸科北京市丰台区芳星园一区6号
  3. ,100078
- 作者简介：
- 基金信息：
  
  国家中医药管理局留学回国人员择优资助项目
- DOI：10.13288/j.11-2166/r.2007.03.039
  中图分类号： R285.5
- 纸质出版：2007
- 稿件说明：
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[1]焦扬,关天宇,周平安.肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β_1的影响[J].中医杂志,2007(03):259-261.

JIAO Yang, GUAN Tian-yu, ZHOU Ping-an. Effect of Feibi Decoction on p38 MAPK and Transforming Growth Factor β₁ of Pulmonary Tissue in Rats with Pulmonary Fibrosis[J]. Journal of Traditional Chinese Medicine2007, (3): 259-261. DOI: 10.13288/j.11-2166/r.2007.03.039.
[1]焦扬,关天宇,周平安.肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β_1的影响[J].中医杂志,2007(03):259-261. DOI： 10.13288/j.11-2166/r.2007.03.039.

JIAO Yang, GUAN Tian-yu, ZHOU Ping-an. Effect of Feibi Decoction on p38 MAPK and Transforming Growth Factor β₁ of Pulmonary Tissue in Rats with Pulmonary Fibrosis[J]. Journal of Traditional Chinese Medicine2007, (3): 259-261. DOI: 10.13288/j.11-2166/r.2007.03.039. DOI：

摘要

目的探讨肺痹汤防治肺纤维化作用及其机理。方法SD大鼠随机分为假手术组

模型对照组

肺痹汤高、中、低剂量组

西药对照组

每组10只。用博莱霉素复制大鼠肺纤维化模型后

肺痹汤高、中、低剂量组每天灌服肺痹汤

西药对照组灌服醋酸强的松

28天后处死大鼠

比较各组大鼠肺组织中p38分裂原激活蛋白激酶（p38 MAPK）以及转化生长因子（TGF-β1）的表达。结果模型对照组大鼠肺组织中p38MAPK及TGF-β1表达均明显高于假手术组及各给药组（P<0.05）

肺痹汤能明显减少大鼠肺组织中p38MAPK以及TGF-β1表达

与模型对照组比较差异具有显著性意义（P<0.05）。结论肺痹汤能明显减少博莱霉素所致的大鼠肺组织中p38MAPK及TGF-β1表达

这可能是其防治肺纤维化的作用机理。

Abstract

Objective To study the effect and mechanism of Feibi Decoction on pulmonary fibrosis.Methods SD rats were randomly divided into sham-operation group

model control group

Feibi Decoction large-close group

Feibi Decoction mid-dose group

Feibi Decoction samll-dose group and western medicine control group

each of 10 rats.Bleomycetin was used to copy rat’s pulmonary fibrosis model.Feibi decoction was drenched to rats in large

medium and small dose of Chinese medicine groups.Prednisone was given to werstern medicine control group.The rats were executed 28 days later.The expression of p38 MAPK and transforming growth factor β1（TGF-β1） was tested.Results In comparison with sham operation

Chinese medicine and western medicine groups

the expression of p38 MAPK and TGF-β1 in model control group increased significantly（P<0.05）.The expression of p38 MAPK and TGF-β1 in Chinese medicine group decreased significantly as compared with model control groups（P<0.05）.Conclusion Feibi Decoction can decrease the expression of p38 MAPK and TGF-β1 of pulmonary tissue in pulmonary fibrosis rats caused by Bleomycetin obviously

which might be the mechanism of Feibi Decoction for prevention and treatment.

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肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β1的影响

Effect of Feibi Decoction on p38 MAPK and Transforming Growth Factor β1 of Pulmonary Tissue in Rats with Pulmonary Fibrosis

DOI：10.13288/j.11-2166/r.2007.03.039

摘要

Abstract

关键词

Keywords

references

肺痹汤对肺纤维化大鼠肺组织中p38分裂原激活蛋白酶及转化生长因子β₁的影响

Effect of Feibi Decoction on p38 MAPK and Transforming Growth Factor β₁ of Pulmonary Tissue in Rats with Pulmonary Fibrosis