Objective To study the effect and mechanism of different combinations of sanchinoside monomers on monocyte-endotheliocyte adhesion.Methods Oxidized low density lipoprotein（ox-LDL）was added to endotheliocytes processed by sanchinoside monomers and their different combinations.Then rose bengal staining was used to detect adhesion of human THP-1 monocytes to human umbilical vein endothelial cells（HUVECs）

and enzymelinked immunosorbent assay was used to detect the expression of intercellular adhesion molecule-1（ICAM-1）.Results Ox-LDL could enhance adhesion of THP-1 to HUVECs.After processed by Rg1 and Rb1

monocyte-endotheliocyte adhesion and expression of ICAM-1 decreased significantly（P<0.05）

especially in combination groups such as Rg1:Rb1

Rg1:R1

and Rb1:R1（P<0.01）.Conclusion Rg1 and Rb1 can obviously inhibit moncyte-endotheliocyte adhesion induced by ox-LDL

especially in different combinations of Rg1

Rb1 and R1.Rg1

Rb1 and their combinations could inhibit monocyte-endotheliocyte adhesion by down-regulating the expression of ICAM-1

which might be related to its protection effect on endotheliocytes.