Objective To study the effect of liver-clearing

heart-draining

yin-enriching and dryness-moistening method on adipocyte resistin and adiponectin and their relations between insulin resistance （IR） in type 2 diabetes patients. Methods Totally 60 patients were randomly and equally divided into two groups. Qinggan Xiexin Decoction was given to treatment group

while Avandia to control group for 2 months. The level of adipocyte resistin and adiponectin were detected by euzymelinked immunosorbent assay and their relations between blood sugar and IR were observed. Results The level of blood sugar decreased in both groups （P<0.01） after treatment

but there was no significant difference between two groups （P>0.05）. Glycosylated hemoglobin decreased in both groups

especially in treatment group （P<0.01）. The level of insulin

C peptide and resistin decreased

while insulin sensitivity index and adiponectin increased significantly in both groups （P<0.01）

but there was no significant difference between two groups （P>0.05）. Conclusion Both Avandia and liver-clearing

heart-draining

yin-enriching and dryness-moistening method can reduce the level of resistin and raise the level of adiponectin for type 2 diabetes. The change of these cytokines is concerned with the relief from IR of type 2 diabetes patients.