Objective To observe the therapeutic effect of Shensifang Decoction for chronic refractory diarrhea and its effect on intestinal flora. Methods Totally 98 patients were randomly divided into two groups. Shensifang Decoction was given to 48 cases of treatment group

while Shenling Baizhu Pill and Sishen Pill to 50 cases of control group. The treatment lasted for 4 weeks. Results The total effective rate and recovery rate were 95.83% and 68.75% in treatment group

which were superior to 68.00% and 26.00% in control group. Integrals of all Chinese medical symptoms and signs improved significantly in treatment group （P<0.01）

while integrals of anepithymia

chill

cold limbs

bland taste

hydroadipsia

languor and laziness to speak improved in control group （P<0.05 or P<0.01）. Intestinal beneficial flora improved significantly in both groups （P<0.05 or P<0.01）

especially in treatment group （P<0.05）. Conclusion Shensifang Decoction has obvious therapeutic effect on chronic refractory diarrhea. It can regulate intestinal flora and reestablish micro-ecological balance.