Objective To study the preventive and therapeutic effect of Prepration of Chinese Allium fistulosum L. （PCAL） on fatty liver （FL） rats and its mechanism. Methods Totally 60 SD rats were randomly divided into blank control group

model control group

small

middle and large dosage of PCAL groups and Dongbao Gantai Tablet group. The rats were fed with high fat diet and water comprised of ethanol and were hypodermically injected with small dosage of carbon tetrachloride to establish FL model. Results As compared with blank control group

the content of total cholesterol （TC）

triglyceride （TG）

malondialdehyde （MDA）

nuclear transcription factor-κB （NF-κB）

transforming growth factor-β （TGF-β） and monocyte chemoattractant protein-1 （MCP-1） mRNA in model control group increased significantly （P<0.05 or P<0.01）

while the activity of superoxide dismutase （SOD） decreased significantly （P<0.01）. As compared with model control group

the content of TC

TG

MDA

NF-κB

TGF-β and MCP-1 mRNA in small

middle and large dosage of PCAL groups and Dongbao Gantai Tablet group decreased significantly （P<0.05 or P<0.01）

while the activity of SOD increased significantly （P<0.01）. Conclusion PCAL has a protective and therapeutic effect on FL rats

which might be relevant to its reducing blood fat

diminishing damage of lipid peroxidation and cytokine.