Objective To study the interventional mechanism of Qiangxinling for ventricular remodeling （VR） after acute myocardial infarction （AMI）. Methods Totally 90 AMI patients were randomly divided into control group of 43 cases and treatment group of 47 cases. The conventional therapy such as distending coronary artery

raising blood flow of coronary artery and treating complication was conducted in control group

while Qiangxinling was added in the treatment group. The therapeutic effect

angiotensinⅡ （AngⅡ）

amino-terminal propeptide of type Ⅲ procollagen （PⅢNP）

transforming growth factor β1 （TGF-β1）

superoxide dismutase （SOD）

left end-diastolic volume index （LEDVI）

left end-systolic volume index （LESVI）

left ventricular ejection fraction （LVEF）

wall motion score index （WMSI） and safety indexes in both groups were observed before and after 6 months’ treatment. Results The total effective rate of treatment group was superior to that of control group （P<0.05）. After treatment

AngⅡ

PⅢNP and TGF-β1 decreased

SOD increased

and LEDVI

LESVI

LVEF and WMSI improved obviously in both groups

especially in treatment group （P<0.05 or P<0.01）. Conclusion Qiangxinling can treat VR after AMI.