XU Shan, ZHOU Jia-he, WANG Chang-song, et al. Correlation between Apoptosis of Gastric Mucosa with Chinese Medical Pattern in Rats with Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2007, (6): 538-541.
XU Shan, ZHOU Jia-he, WANG Chang-song, et al. Correlation between Apoptosis of Gastric Mucosa with Chinese Medical Pattern in Rats with Chronic Atrophic Gastritis[J]. Journal of Traditional Chinese Medicine2007, (6): 538-541.DOI: 10.13288/j.11-2166/r.2007.06.033.
Objective To explore pattern essence from the aspect of apoptosis by observing apoptosis of gastric mucosa and expression of modulin in chronic atrophic gastritis (CAG) rats with different Chinese medical patterns. Methods CAG rat models with spleen deficiency pattern
liver depression pattern and damp heat pattern were copied respectively. Apoptosis of gastric mucosa and expression of Bcl-2 and Fas were detected. Results Apoptosis indexes of gastric mucosa and expression of Bcl-2 and Fas in model groups
especially in CAG with spleen deficiency group
were higher than those in normal control group. Conclusion There is correlation between apoptosis index of gastric mucosa and expression of Bcl-2 and Fas with Chinese medical pattern in CAG rats. Apoptosis index of gastric mucosa and expression of Bcl-2 and Fas is the highest in CAG with spleen deficiency group.