Objective To observe the therapeutic effect of Najia method of midday-midnight point selection for acute ischemic cerebrovascular disease（AICD） and its effect on hemorheology

interleukin-6 （IL-6）

thromboxane B2 （TXB2） and 6-keto-prostaglandin1α （6-keto-PGF1α）.Methods Totally 90 AICD patients were randomly and equally divided into three groups. Conventional therapy was used in medicine group

point selection by affected-channel was added in affected-channel group and midday-midnight point selection was added in Najia group.Results The total effective rate of Najia group was 96.67%

which was superior to 73.33% of medicine group （P<0.01）. The total effective rate of affected-channel group was 90%. The recovery and marked improvement rates of Najia group were superior to those of medicine and affected-channel groups（P<0.05 or P<0.01）. The improvements of whole blood viscosity and rate of red blood cell deformation in Najia group were superior to those in other two groups （P<0.05）. IL-6

TXB2 and 6-keto-PGF1α improved significantly in three groups（P<0.05 or P<0.01）. 6-keto-PGF1α and IL-6 in Najia group improved significantly at the early stage of treatment （P<0.05）.Conclusion Najia method of midday-midnight point selection is effective for AICD and can improve hemorheology

decrease the level of IL-6

recover dynamic equilibrium of TXB2 and 6-keto-PGF1α and promote the recovery of cranial nerves.