WANG Jun, LIU Hui-xia, ZHANG Wei, et al. Protection of Essential Oil of Fresh Ginger against Cerebral Ischemia Reperfusion Injury[J]. Journal of Traditional Chinese Medicine2007, (7): 644-646.
WANG Jun, LIU Hui-xia, ZHANG Wei, et al. Protection of Essential Oil of Fresh Ginger against Cerebral Ischemia Reperfusion Injury[J]. Journal of Traditional Chinese Medicine2007, (7): 644-646.DOI: 10.13288/j.11-2166/r.2007.07.037.
Objective To study the protection of essential oil of fresh ginger against cerebral ischemical reperfusion injury (CIRI).Methods Mouse CIRI models were established by ligating bilateral common carotid artery. The activity of Na+
K+-ATPase
Ca2+-ATPase and superoxide dismutase (SOD) and content of malondialdehyde (MDA) were detected by chemical colorimetric assay.Results As compared with sham operation group
the activity of Na+
K+-ATPase and Ca2+-ATPase in model control group decreased significantly (P<0.01)
but there was no obvious change in activity of SOD and content of MDA. Volatile oil of fresh ginger could increase the activity of Na+
K+-ATPase
Ca2+-ATPase and SOD and decrease the content of MDA significantly (P<0.05 or P<0.01).Conclusion Essential oil of fresh ginger has protective effect against CIRI by enhancing the activity of ATPase and resisting oxidation.