Objective To observe the therapeutic effect of herbal medicine and psychotherapy on females with insomnia during menopause stage. Methods Totally 129 patients were randomized into two groups. The 76 patients of treated group were treated by herbal medicine Modified Baoshen Yumei Yin and psychotherapy. The 53 patients of control group were administered Surazepam for oral taking. The clinical comprehensive therapeutic effect

TCM syndrome therapeutic effect

the improvement of sleep quality

and the adverse effect were taken as indices to observe the clinical effect for comparison. Results The clinical comprehensive therapeutic effect of treated group was obviously better than that of control group （P<0.05）. Conclusion The herbal medicine and psychotherapy could enhance the therapeutic effect of treatment on female patients with insomnia during menopause.