Objective To study effects and mechanism of Fengbei Huayu Capsule on microangiopathy caused by diabetes （DM） in Rats. Methods Wistar rats were devided into five groups including the control group

DM model group

Chinese medicine treatment group

positive Chinese medicine treatment control group and positive western medicine treatment control group. Serum glucose

blood fat

lipid peroxidation

dead end product of glycosylation

aldose reductase （AR） and related gene expressions were determined. Results The DM model group of rats showed increase of serum glucose

triglyceride

glycosylated hemoglobin

activity of AR and malonaldehyde（MDA） as well as the increase of gene expression of FasL and TNF-α and apoptosis rates of T cells. However

the tested targets in Chinese medicine treatment group signficantly decreased （P<0.05）after the treatment with Chinese medicine. Conclusion Fengbei Huayu Capsule could effectively decrease related gene expression and diabetes-caused increase of serum glucose

blood fat

lipid peroxidation

glycosylated hemoglobin

activity of AR and MDA

as well as apoptosis rats of T cells in DM rats. It has good therapeutic effects on microangiopathy caused by diabetes.