Objective To study the effect of Ditan Kaiqiao Decoction on the behavioral ability and intracerebral neurotransmitter of rats with post-stroke depression（PSD）. Methods After the permanent ligation of bilateral common carotid arteries was performed

the behavioral limitation was applied to make PSD model rat and they were randomized into Model group

Ditan Kaiqiao group

Fluoxetine group and Pseudooperation group. The changes of monoamine neurotransmitter of hippocampal region were tested by RP-HPLC fluoroscopic examination and the autonomy behavioral changes were observed. Results The behavioral ability of Model group decreased （P<0.01 or P<0.05）. 5-HT

5-HIAA

DA and NE of hippocampal region were lowered （P<0.05）. With the treatment of fluoxetine hydrochloride and Ditan Kaiqiao Decoction

the horizontal movement

vertical movement and clean movement of rats were improved in comparison with Model group

while the intracerebral monoamine neurotransmitter increased （P<0.05）. Conclusion The permanent ligation of bilateral common carotid artery in combination of behavioral limitation could provide the ideal animal models for experiment and clinical study of PSD. Ditan Kaiqiao Decoction could improve the behavioral ability and intracerebral neurotransmitter of PSD rats.