Objective To observe the effect of Shugan Yangwei Tongmai Granules（Granule for Soothing Liver

Nourishing Stomach and Removing Obstruction） on expression of DNA mismatching gene hMSH2 protein in chronic atrophic gastritis（CAG） patients.-Methods The S-P immunohistochemical method was used to test the hMSH2 protein expression of 174 atypical CAG cases.-Results In the treatment group

with the atrophy aggravation

heterotype increase and Hp infection intensify

the decrease of over-expression of hMSH2 protein was increased after treatment（P<0.05）.In metaplasia

the intestinal and pseudopyloric gland metaplasia was aggravated

the decrease of over-expression of hMSH2 protein of nucleolus showed a negative correlation

i.e.that of the simple group was significant（P<0.01）

that of the cytoplasm in the medium group was significant（P<0.01）

and in the severe group it was decreased

but not significantly（P>0.05）.In the control group

the over-expression of hMSH2 protein of nucleolus and cytoplasm was decreased to a certain degree

but the in-group comparison correlation was not significant（P>0.05）.-Conclusion The Chinese herbal medicine Shugan Yangwei Tongmai Granules could inhibit and kill Hp and decrease the over-expression of hMSH2 protein of CAG

especially for those accompanied with atypical hyperplasia

being effective for treating CAG and prevent its carcinogenesis.