Objective To explore the effects of apolipoprotein E gene polymorphism on serum concentration of lipids and lipid-adjusting effect of correspond medicine in hyperlipidemia patients with phlegm and blood stasis syndrome in the Han nationality in north china.Methods Totally 172 cases of hyperlipidemia patients with phlegm and blood stasis syndrome were randomly divided into observation group（n=87）and control group（n=85）.The observation group was treated by Tiaozhi Tongmai Granule.The control group was treated by Xuezhikang Capsule.Clinical symptom and serum concentration of lipid were observed before and after treatment.Using PCR-RFLP methods

we analyzed the forth extron genotypes of ApoE gene in 172 cases.Results In hyperlipidemia patients with phlegm and blood stasis syndrome

serum concentration of lipid in observation group and control group were greatly improved after treatment.The total effective rate of observation group was superior to that of control group（P

<

0.01）.Before treatment

serum LDL-C concentration of ApoE E3/3 and E3/4 genetype was significantly higher than that of the E2/3（P

<

0.05

0

.01）.The serum LDL-C concentration of E3/4 genetype was more significantly improved than that of the E2/3 and E3/3 genetype（P

<

0.01）.Conclusion Sensitivity of lipid-adjusting effect of correspond medicine differed due to different ApoE genotype in hyperlipidemia patients with phlegm and blood stasis syndrome

indicated that heredity factor plays an important role.