Objective To observe the influence of Nourishing Yin and Promoting Blood Circulation Formula on ventricular remodeling of transgenic mice with mineralocorticoid receptor overexpression.Methods The mice were divided into three groups:male non-transgene（NTG）group

male transgene（TG）group

and male transgene + Chinese medicine（TG+herbs）group.After myocardial infarction model-making

the heart weight

ratio of heart weight to body weight

mRNA expression of brain natriuretic peptide

survival rate and heart pathological section were observed.Results With the herbal treatment to nourish yin and promote blood circulation

the heart weight and the ratio of heart weight to body weight of the TG+herbs group was significantly different from those of TG group（P<0.05）

but the difference was not significant in comparison with NTG group（P>0.05）.The mRNA expression of brain natriuretic peptide of TG+herbs group was weakened than that of TG group（P<0.05）

but the difference was not significant in comparison with NTG group（P>0.05）.The survival rate of TG+herbs group was higher than that of TG group（P<0.05）

but the difference was not significant in comparison with NTG group（P>0.05）.The heart pathological section showed an obvious fibrosis in TG group

a relieved fibrosis in TG+herbs group and a least fibrosis in NTG group.Conclusion The herbal treatment to nourish yin and promote blood circulation can relieve the ventricular remodeling of male TG mice with MR overexpression after myocardial infarction.