益肾活血法对频复发性肾病患儿皮质醇、血栓素B<sub>2</sub>、6-酮-前列腺素<sub>1α</sub>的影响

郑健; 魏金花; 吴群励; 边莉

doi:10.13288/j.11-2166/r.2007.10.054

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益肾活血法对频复发性肾病患儿皮质醇、血栓素B₂、6-酮-前列腺素_1α的影响

临床研究 | 更新时间：2021-11-17

- 益肾活血法对频复发性肾病患儿皮质醇、血栓素B₂、6-酮-前列腺素_1α的影响
- Effect of Reinforcing Kidney and Activating Blood Method on Hydrocortisone,TXB₂ and 6-keto-PGF_1α in Children FRNS
- 中医杂志 2007年第10期页码：895-897
- 作者机构：
  
  1. 福建中医学院附属人民医院儿科
  2. 福建中医学院附属人民医院儿科福州市817中路602号
  3. ,350004
- 作者简介：
- 基金信息：
  
  福建省教育厅课题（JA019082）
- DOI：10.13288/j.11-2166/r.2007.10.054
  中图分类号： R272
- 纸质出版：2007
- 稿件说明：
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[1]郑健,魏金花,吴群励,边莉.益肾活血法对频复发性肾病患儿皮质醇、血栓素B_2、6-酮-前列腺素_(1α)的影响[J].中医杂志,2007(10):895-897.

ZHENG Jian, WEI Jin-hua, WU Qun-li, et al. Effect of Reinforcing Kidney and Activating Blood Method on Hydrocortisone,TXB₂ and 6-keto-PGF_1α in Children FRNS[J]. Journal of Traditional Chinese Medicine2007, (10): 895-897. DOI: 10.13288/j.11-2166/r.2007.10.054.
[1]郑健,魏金花,吴群励,边莉.益肾活血法对频复发性肾病患儿皮质醇、血栓素B_2、6-酮-前列腺素_(1α)的影响[J].中医杂志,2007(10):895-897. DOI： 10.13288/j.11-2166/r.2007.10.054.

ZHENG Jian, WEI Jin-hua, WU Qun-li, et al. Effect of Reinforcing Kidney and Activating Blood Method on Hydrocortisone,TXB₂ and 6-keto-PGF_1α in Children FRNS[J]. Journal of Traditional Chinese Medicine2007, (10): 895-897. DOI: 10.13288/j.11-2166/r.2007.10.054. DOI：

摘要

目的观察益肾活血中药肾康灵对频复发性肾病（FRNS）血栓素B2（TXB2）患儿、6-酮-前列腺素F1α（6-keto-PGF1α）及皮质醇的影响

探讨FRNS的发病机理及益肾活血法干预治疗的作用机制。方法收集25例FRNS患儿分为治疗组和对照组

选择10名健康儿童（健康对照组）作为正常对照。观察治疗组和对照组在治疗前后血皮质醇及血和24小时尿TXB2、6-keto-PGF1α

以及血浆白蛋白、血胆固醇等的变化。结果治疗组和对照组治疗前血浆皮质醇、血和尿TXB2、尿6-keto-PGF1α、血和尿TXB2/6-keto-PGF1α比值与健康对照组比较差异有显著性意义（P<0.01）;治疗后两组血浆皮质醇、血和尿TXB2、血6-keto-PGF1α、血和尿TXB2/6-keto-PGF1α比值与治疗前比较差异有显著性意义（P<0.01或P<0.05）;治疗后治疗组与对照组比较

血TXB2、血和尿6-keto-PGF1α、血TXB2/6-keto-PGF1α比值差异有显著性意义（P<0.01或P<0.05）。结论FRNS患儿存在血皮质醇低下

TXB2/PGF1α失衡

益肾活血中药肾康灵干预治疗能明显提高血皮质醇、纠正TXB2/PGF1α失衡、改善血液高凝状态。

Abstract

Objective To observe the effect of Shenkangling（Herbs for Kidney Disease）on changes of thromboxane B2（TXB2）

6 ketone prostaglandin F1α（6-keto-PGF1α）and hydrocortisone in frequently Relapsing Nephrotic Syndrome（FRNS）

and to study the mechanism of FRNS and the functional mechanism of herbal medicines.Methods The 25 cases of children FRNS were divided into treatment groups and control group

and 10 healthy children were taken in the normal control group.The changes of plasma hydrocortisone

blood and 24h urine TXB2

6-keto-PGF1α

AlB and cholesterol of the treatment and the control group before and after treatment were observed.Results Before treatment

compared with the normal control group

the difference in plasma hydrocortisone

blood and urine TXB2

urine 6-keto-PGF1α

and the ratio of blood and urine TXB2 to 6-keto-PGF1α of the treatment group and the control was significant（P<0.01）.After treatment

plasma hydrocortisone

blood and urine TXB2

blood 6-keto-PGF1α

and the ratio of blood and urine TXB2 to 6-keto-PGF1α of both treated groups was significantly improved（P<0.01 or P<0.05）.After treatment

difference between the treated groups in blood TXB2

blood and urine 6-keto-PGF1α

and the ratio of blood TXB2 to 6-keto-PGF1α was significant（P<0.01 or P<0.05）.Conclusion In children FRNS

there exists the lowered blood hydrocortisone and imbalance of TXB2/PGF1α.The herbal treatment with Shenkangling based on the principle of Reinforcing kidney and activating blood can greatly increase blood hydrocortisone and correct the imbalance of TXB2/PGF1α to improve the highly coagulated state of blood.

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益肾活血法对频复发性肾病患儿皮质醇、血栓素B2、6-酮-前列腺素1α的影响

Effect of Reinforcing Kidney and Activating Blood Method on Hydrocortisone,TXB2 and 6-keto-PGF1α in Children FRNS

DOI：10.13288/j.11-2166/r.2007.10.054

摘要

Abstract

关键词

Keywords

references

益肾活血法对频复发性肾病患儿皮质醇、血栓素B₂、6-酮-前列腺素_1α的影响

Effect of Reinforcing Kidney and Activating Blood Method on Hydrocortisone,TXB₂ and 6-keto-PGF_1α in Children FRNS