Objective To study the relation between apolipoprotein E（ApoE） gene polymorphism and the effect of Qishen Yiqi Droplet（Droplet mainly containing Huangqi and Danshen for Reinforcing Qi） for qi deficiency with blood stasis syndrome of coronary heart disease.Methods The 49 patients conformed to the diagnosis standard of coronary heart disease were treated with Qishen Yiqi Droplet for one month.The white blood cell DNA was extracted from the blood sample and the 4th exon of ApoE gene was tested for finding its polymorphism locus with sequencing.Results Two significant mutable sites were noticed:the mutation of the 2888th site was remarkably related to the therapeutic effect of shortness of breath and general lassitude while that of the 2903rd site to the thera- peutic effect of chest pain and spontaneous sweating.Conclusion ApoE gene polymorphism was related to the effect of qi deficiency with blood stasis syndrome of coronary heart disease treated by

Qishen Yiqi Droplet.