Objective To observe the effect of Huangqi （Radix Astragali seu Hedysari） Injectio on the abnormal expression of aquaporin-1 （AQP-1） caused by glucose lactate peritoneal dialysis solution. Methods Different glucose concentration lactate peritoneal dialysis solutions and Huangqi Injectio given to the rats intraperitoneally. Eight weeks later

the ultrafiltration of peritoneal dialysis

peritoneum clearance

peritoneal structure

AQP-1 and its gene expression were observed. Results Compared with the control group

in the glucose and Huangqi groups

the ultrafiltration of peritoneal dialysis was remarkably decreased （P<0.05）; in the high glucose group

urea nitrogen clearance was remarkably lower （P<0.05）. After the dialysis

the injuries of peritoneal structure in different degrees existed

especially worse in the high glucose group. The AQP-1 expression in the high glucose and high Huangqi group was remarkably decreased in comparison with the control group （P<0.05）. Conclusion The Huangqi Injectio can protect the peritoneum

but its definite function on the AQP-1 expression is not yet determined.