Objective To study the effects of simultaneous treatment of phlegm and stasis on the changes of blood fat

tissue plasminogen activator（t-PA）and plasminogen activator inhibitor（PAI）

platelet agglutinate rate and hemorheology in atherosclrotic rabbits.Methods The 50 white rabbits were divided randomly into five groups with 10 in each:blank control group

model group

Di’ao Xinxuekang（0.02g/kg）group

phlegm and stasis simultaneous treatment small and large dose（7.5g/kg

15g/kg）groups.After four weeks’ high-fat feedstuff feed

the rabbits were given medicine gavage per day for 4 weeks and then killed.The blood fat

t-PA and PAI

platelet agglutinate rate and hemorheology were measured.Results The phlegm and stasis simultaneous treatment in the treated group could significantly improve the level of blood fat

increase t-PA and decrease PAI

significantly inhibit the platelet one minute agglutinate rate and maximum agglutinate rate

significantly decrease the whole blood high cut rate and low cut rate viscosity

whole blood revert viscosity

platelet adhesion

and erythrocyte sedimentation rate（ESR）in atherosclerosis（AS）rabbit.Conclusion Simultaneous treatment of phlegm and stasis can prevent AS through improving abnormal blood fat

increasing fibrinolytic activity

inhibiting platelet aggregation

and improving microcirculation.