Objective To compare the therapeutic effect of auricular acupuncture with that of hormone substitution on perimenopause syndrome patients to study the mechanism of auricular therapy.Methods Totally 68 female cases were randomized into the auricular acupuncture group and hormone group

34 cases in each.The auricular acupuncture group was given electro-acupuncture on Neifenmi（CD18）

Ovarium

and Uterus;and the hormone group was given Tibolone.Before and after treatment

record Kupperman score and determine serum estradiol（E2）

follicle-stimulating hormone（FSH）and luteotropic hormone（LH）respectively.Results After treatment

the Kupperman scores of both groups were decreased

the level of E2 increased obviously

FSH and LH decreased

the difference was significant（P<0.05

P<0.01）.The level of E2 in the auricular acupuncture group after treatment was lower than that of hormone group（P<0.05）.The therapeutic effect of auricular acupuncture group and hormone group was not significantly different（P>0.05）.Conclusion The auricular therapy can effectively relieve the perimenopause syndrome and improve the reproductive endocrine function of perimenopause females.