Objective To establish the disease-syndrome integrated animal models suitable for the studies of TCM through differen- tiating the property of TCM syndromes of spontaneous diseased animal models.Methods With the observation on general behaviors

irritable degree

turning endurance time

pain threshold

urine and stools

luster of hair

growing speed of hair

body weight

tongue condition

degree of eyeball protruding

conjunctiva chroma

blood pressure

heart rate

etc.of spontaneous hypertension rats（SHR） and the comparison with normal rats

the study was carried out on the macroscopic description of property of TCM syndrome of SHR （14～18 weeks of age）and their ethology.Results The blood pressure of SHR at the early stage tended to raise with age growing. Compared with the normal group

the heart rate of SHR rats was obviously quicker（P<0.05 or P<0.01）.Increased irritability and pain threshold

stress

decreased turning endurance time

serious eyeball protruding

light colored conjunctiva

reduced weight

yel- lowish hair without luster

falling of hair

yellow urine

smaller and dry granules of stools

and red tongue

were found in SHR rats at early stage.Conclusion The property of TCM syndrome of SHR at the age of 14～18 weeks is similar to the syndrome of liver fire flaring-up of human.