Objective To observe the effect of Yishen Paizhuo Decoction（Decoction for reinforcing the kidney and discharging the turbid）on chronic renal failure（CRF）patients.Methods The 82 CRF patients were randomized into observation group（42 cases） and control group（40 cases）.In addition to the routine treatment

the observation group was administered modified Yishen Paizbuo Decoction

and the control group was given coated aldehyde oxystarch.The course of treatment was 6 months for both groups. Changes of clinical symptoms

renal functions

blood fat

and hemoglobin were observed

and the linear regression evaluation and renal survival evaluation were employed to evaluate the development of CRF.Results The improvement of observation group in renal func- tions and blood fat was remarkable with the increased renal survival rate

compared with the control group

the difference was signifi- cant（P<0.05 or P<0.01）.Conclusion Yishen Paizhuo Decoction can improve the symptoms of CRF patients and remove metabol- ic products

thus slowing down the development of renal failure.