Objective To observe the effect of Chinese Medicines with the function of antioxidation on lupus nephritis（LN）pa- tients.Methods The 25 LN patients consisting of renal function normal group（15 cases）and renal failure group（10 cases）were treated with Huang Qi（Radix Hedysari）and Shu Dihuang（Radix Rehmanniae Praeparata）as main ingredients for 6 months in suc- cession.Changes of symptom

systemic lupus erythematosus disease activity index（SLEDAI）

activity index（AI）

lipid peroxide （LPO）

superoxide dismutase（SOD）

glutathione peroxide（GSH-Px）

malondialchehyche（MDA）

nitric oxide（NO）

blood and urine routine examination

24-hour urine protein quantity

liver and kidney function

anti-double-stranded DNA（anti ds-DNA）

complement 3（C

3

）and complement 4（C

4

）

after treatment were observed.Results SLEDAI and AI scores were remarkably different from those before treatment（P

<

0.01）.After treatment

NO

MDA and anti-ds-DNA of both groups were extremely decreased

SOD

GSH-Px and reduced GSH were extremely increased（P

<

0.05 or P

<

0.01）.LPO and urine protein of the renal function normal group were greatly decreased and C

3

increased（P

<

0.05）.Conclusion The effect of Chinese Medicines with the function of antioxidation is effec- tive in relieving SLE and delaying renal function failure

but is less effective for LN patients with renal failure and they are ineffective for those with V-type of LN in histopathology.