Objective To observe the effect of Tangluotong Decoction（Decoctions of removing obstruction of meridians for treating diabetes）based on the principle of reinforcing kidney

activating blood and removing obstruction of meridians on the early diabetic nephropathy（DN）patients.Methods Totally 68 DN patients were randomized into two groups.In addition to the routine treatment for diabetes

the treatment group（38 patients）was administered Tangluotong Decoction while the control group（30 patients）was giv- en Lossartan Potassium Tablets.The clinical symptoms and signs and lab indices before and after treatment were observed.Results The comprehensive total effective rate of the treatment group was 89.47% while that of control group was 60.00%

the difference was significant（P

<

0.01）.The difference of total effective rate of single symptoms in Chinese medicine between two groups were also sig- nificant（P

<

0.05）.The effect of Tangluotong Decoction was also good in decreasing urineβ

2

microglobulin（β

2

-MG）

plasma endothe- lin（ET）and nitrous oxide（NO）

and the difference between two groups was significant（P

<

0.05）.Conclusion Tangluotong De- coction has definite effect on early DN

indicating that the principle of reinforcing kidney

activating blood and removing obstruction of meridians functions well for it.