LI Chun-ting QIAN Hua LUO Shu. Effect of Renzhu Jianwei Granules on Carcinoembryonic Antigen and Cyclooxygenase 2 of the Patients with Precancerous Lesions of Gastric Cancer[J]. Journal of Traditional Chinese Medicine2008, (5): 428-430.
LI Chun-ting QIAN Hua LUO Shu. Effect of Renzhu Jianwei Granules on Carcinoembryonic Antigen and Cyclooxygenase 2 of the Patients with Precancerous Lesions of Gastric Cancer[J]. Journal of Traditional Chinese Medicine2008, (5): 428-430.DOI: 10.13288/j.11-2166/r.2008.05.056.
Objective To explore the effect of Renzhu Jianwei Granules(Granule of Semen Coicis and Rhizoma Atractylodis Macro- cephalae for strengthening the stomach)on the patients with precancerous lesions of gastric cancer(PLGC)and its mechanism. Methods The 58 patients of chronic atrophic gastritis(CAG)complicated with intestinal metaplasia(IM)and/or dysplasia(Dys) were randomized into treatment group and control group with 29 in each.The treatment group was administered Renzhu Jianwei Gran- ules while the control group was given Weifuchun Tablets.The numbers of positive cells of carcinoembryonic antigen(CEA)and cy- clooxygenase 2(COX-2)of gastric mueosa before and after treatment were observed.Results The scores of positive cells of CEA and COX-2 of gastric mucosa of both groups were greatly reduced after treatment(P<0.05)
but the difference between the two groups was not significant(P>0.05).Conclusion Renzhu Jianwei Granules can reduce CEA and COX-2 of PLGC patients
possibly being one of the mechanisms in treating PLGC.