Objective To observe the effect of Bushen Yiqi Hexue Recipe（Recipe to reinforce kidney

replenish qi and harmonize blood）on the endometrial gland apoptosis in blastocyst implantation dysfunctional mice.Methods The mice models of blastocyst implantation dysfunction were made and divided into control

model and treated groups with 30 in each.Pregnancy rate

number of implantation blastocysts

the expression of proliferating cell nuclear antigen（PCNA）

bax

bcl-2 and activated Caspase-3 were observed.Results Compared with the control group

pregnancy rate and mean implanted blastocysts in the model group were remarkably reduced.Compared with the model group

pregnancy rate and mean implanted blastocysts in the treated group were significantly improved（P<0.05

P<0.01）.Comparing with the control group

proliferation index（PI）of endometrial gland in the model group was dramatically elevated（P<0.01）

whereas apoptosis index（AI）was dramatically reduced（P<0.05）.Comparing with the model group

PI of endometrial gland in the treated group was obviously inhibited

while AI was significantly improved（P<0.01）

both showed no remarkable difference from those of control group.Bax and activated Caspase-3 protein expressions of endometrial gland in the model group was remarkably lower than in the control group（P<0.01）

and these expressions in the treated group was significantly higher than in the model group（P<0.01）

but there was no significant difference in comparison of the treated group with the control group.Conclusion It is suggested that increasing bax and activated Caspase-3 expression and regulating the imbalance of apoptosis and proliferation in endometrial gland may be one of the mechanisms of Bushen Yiqi Hexue Recipe in improving uterine receptivity and eventually promoting blastocyst implantation.