Objective To observe the effect of Dangui Huoxue Zhitong Granule（Granule of Radix Salviae Miltiorrhizae and Ramulus Cinnamomi for activating blood circulation to stop pain）on pain

inflammation and injury of soft tissues.Methods Animal models of inflammation

pain and traumatic injury of soft tissues were adopted for observing the twisting reaction after intraperitoneal injection of acetic acid

pain threshold of hot-plate test

auricular selling of mice and metatarsal swelling of rats.Results Dangui Huoxue Zhitong Granule could decrease conspicuously the twisting reactions

increase the pain threshold（P<0.05）

relieve the auricular selling of mice and the metatarsal swelling of rats

inhibit the mice abdominal capillary hyperpermeability caused by acetic acid（P<0.05）

and relieve the swelling of involved limbs

blood stasis and swelling of muscles of rats with soft tissue injury（P<0.05）.Conclusion Dangui Huoxue Zhitong Granule is effective in analgesia

anti-inflammation and anti-injury of soft tissues.