Objective To observe the effect of herbal treatment with Clearing pathogens

activating blood and astringing ulceration on ulcerative colitis （UC）.Methods The 100 UC patients were randomized into the control group（45 cases） treated by sulfasalazine entericcoated tablet enema once a day

and the treatment group（55 cases） treated by the enema with the herbal decoction in the principle of clearing pathogens and activating blood for treating ulceration once a day.Both groups were orally administered the basic herbal treatment with 30 days as one course.The effect of two groups was compared after treatment and the improvement of pathological changes of intestinal mucosa were observed with endoscope.Results The effect of treatment group was better in relieving symptoms of TCM syndrome and intestinal mucosa than that of control group （P<0.01 or P<0.05）.Conclusion Qinghua Huoxue Lianyang therapy is good for UC and it can repair well the lesion of intestinal mucosa.