Objective To observe the effect of benefiting kidney and dredging meridian method on expression of proinflammatory cytokine genes of Chronic abacterial prostatitis（CAP） model rats.Methods The 60 Wistar rats were randomized into normal control group

model control group

high and low dosage groups of Qianlie Tongli Decoction

and positive control group.The high and low dosage groups of Qianlie Tongli Decoction were administered herbal medicine for one month in succession 45 days after making models.The pathological changes in the prostate tissue of all groups were observed with light microscope and electron microscope

and the expression of TNF-α

IL-1β

IL-2

and iNOs of inflammatory gene was tested.Results In the high dosage group

TNF-α

IL-1β

IL-2 and iNOs tended to be normal

the pathological inflammatory changes of histology were greatly relieved or restored to normal state.Compared with the model control group

the difference was significant.Conclusion Qianlie Tongli Decoction with the principle of benefiting kidney and dredging meridian is therapeutically effective for the experimental CAP rats through inhibiting the expression of proinflammatory cytokine genes to regulate the immune function.