Objective To discuss the clinical effect of combination therapy under the theory of "treating soft tissue for bone disease" on knee osteoarthritis.Methods The 160 cases were randomly divided into control group（80 cases） and experimental group（80 cases）.The control group was treated by diclofenac sodium sustained release capsules（per os） and sodium hyaluronate（intra-joint injection）.The experimental group was treated by traction

steaming and washing

massage

needle-knife therapy

manipulation on soft tissues for loosening the joint

and orthepedic insoles.The course of treatment was 3 weeks.The effect was evaluated according to Lysholm Score

knee movement and subjective satisfaction after the follow-up for 6 months.Results Of the 154 cases completed the study（control group 75 cases and experimental group 79 cases）

the Lysholm Score and knee movement had a very significant improvement（P<0.05 or P<0.01）

but with a better result in the experimental group（P<0.05）.The subjective satisfaction of the experimental group was also higher than that of the control group（P<0.05）.Conclusion combination therapy under the therapy of "Treating Soft Tissue for Bone Disease" is effective for knee osteoarthritis.