Objective To study the mechanism of reinforcing kidney and activating blood therapy for the apoptosis of endometriosis.Methods Female SD rats aged 8

1

2weeks were grouped as model group

western medicine group

Chinese medicine group and integrated Chinese and western medicine group

with 15 in each group.The light microscope

electron microscope

TUNEL method

and immunohistochemical method were adopted to observe the pathomorphology

positive rate of apoptotic cells and the positive expression of apoptosis-regulating gene bcl-2 and bax.Results The apoptosis of endometriosis tissues in the integrated Chinese and western medicine group was the most obvious result with the highest apoptosis index

and the positive expression of apoptosis regulating gene bcl-2 was downward regulated and that of apoptosis regulating gene bax upward regulated

so bcl-2/bax decreased.Then it was Chinese medicine group

western medicine group

and model group.Conclusion The occurrence of endometriosis is related with the lowering of ability of apoptotic cells.Chinese medicines with the functions to reinforce kidney and activate blood can promote the ability of apoptotic cells in endometriosis to quicken the atrophy and regression of endometriosis tissues.