Objective To observe the protection of Qingre Baidu（Clearing heat to detoxicate） Mixture on mice infected with Staphylococcus Aureus.Methods The 168 mice were randomized into Qingre Baidu Mixture large

medium and small dosage groups

Amoxicillin group

Liushen Pill group

Model group and Normal control group.Except the normal control group

other groups were injected intraperitoneally Staphylococcus Aureus to make bacteremia models in order to observe the mortality of mice and the antibacterial effect in vitro of the mixture.The flow cytometry was used to observe the quantitative changes of CD3+

CD4+ and CD8+ T lymphocytes in peripheral blood in Qingre Baidu Mixture large dosage group

A

g

roup

L

g

roup

M

g

roup and N

g

roup of totally 80 mice.Results The mortality of Qingre Baidu Mixture large dosage group

Liushen Pill group A

g

roup

and N

g

roup was obviously lower than that of the model group（P

<

0.05 or P

<

0.01）.The recovery rate of Qingre Baidu Mixture on Staphylococcus Aureus was less than 70%.CD3+ level of Qingre Baidu Mixtuer large-dosage group was obviously higher than that of the model control group（P

<

0.05）

and the CD4+、CD4+/CD8+、CD8+ levels had no significant differences compared with the model control group （P

>

0.05）.The CD3+、CD4+/CD8+、CD8+ expression of Qingre Baidu Mixture large-dosage group had no significant difference with Liushen Pill group

Amoxicillin group and normal control group（P

>

0.05）;The CD4+ levels of Qingre Baidu Mixture large-dosage group were lower than Liushen Pill group

Amoxicillin group and normal control group（P

<

0.05）.The CD3+、CD4+、CD4+/CD8+ levels of Liushen Pill group

Amoxicillin group and normal control group were obviously higher than those of the model control group（P

<

0.05）

and the CD8+ levels of Liushen Pill group

Amoxicillin group and normal control group had no obvious differences with thd model control group（P

>

0.05）.Conclusion Qingre Baidu Mixture has a protection function on mice infected by Staphylococcus Aureus and its mechanism may be related with the antibacterial function and improving immunity of Qingre Baidu Mixture.